Biography of d3 vitamin
Research has shown that in terms of the amount of vitamin D in the blood, a daily supplement of vitamin D is more effective than larger weekly or monthly supplementations.
Vitamin-D supplements are generally recommended for:
- Children aged 0 – 2 years (vitamin D as drops)
- Pregnant women
- Children and adults with dark skin
- Children and adults who wear fully covering clothes in the summer time
- People who do not spend time outdoors in the daytime or generally avoid sunlight
- Nursing home residents
- People older than 70 years
- Anyone who, regardless of their age, are at increased risk for osteoporosis
Vegans and vegetarians are advised to adhere to the official guidelines for sun exposure and possibly take a supplement of vitamin D during the winter period.
Blood levels of vitamin D can be determined by a blood test that measures the unit 25-hydroxyvitamin D (25-(OH)D) and is expressed in nmol/l. Vitamin D status is graduated in the following way:
- <12 nmol/l: Severe deficiency
- 12-25 nmol/l: Deficiency
- 25-50 nmol/l: Insufficient
- >50 nmol/l: Sufficient
- 75-150 nmol/l: Optimal level in individuals with fragile bones and kidney patients
- >ca. 200 nmol/l: Risk of overdose
> = greater than
< = less than
Conversion
1 nmol/l = 0,4 ng/ml
Measurement of vitamin D
The safest way to know one's vitamin D status is by means of a blood test. However, for normal, healthy individuals there is no immediate need to measure blood levels of vitamin D. For certain groups, however, it is advisable to gauge their vitamin D status.
For instance, people with a lifestyle that gives reason to believe that they could benefit from checking their status. Besides the obvious factors that limit vitamin D such as lack of sunlight and poor diet, there are more subtle causes such as the fact that some types of medicine may affect the body’s vitamin D absorption, thereby increasing the need for this particular nutrient.
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Cholecalciferol
Vitamin D3, a chemical compound
Pharmaceutical compound
| Pronunciation | |
|---|---|
| Other names | vitamin D3 |
| AHFS/Drugs.com | Professional Drug Facts |
| License data | |
| Routes of administration | By mouth, intramuscular |
| ATC code | |
| Legal status | |
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| CAS Number | |
| PubChemCID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.000.612 |
| Formula | C27H44O |
| Molar mass | 384.648 g·mol |
| 3D model (JSmol) | |
| Melting point | 83 to 86 °C (181 to 187 °F) |
| Boiling point | 496.4 °C (925.5 °F) |
| Solubility in water | Practically insoluble in water, freely soluble in ethanol, methanol and some other organic solvents. Slightly soluble in vegetable oils. |
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Cholecalciferol, also known as vitamin D3 or colecalciferol, is a type of vitamin D that is produced by the skin when exposed to UVB light; it is found in certain foods and can be taken as a dietary supplement.
Cholecalciferol is synthesised in the skin following sunlight exposure. It is then converted in the liver to calcifediol (25-hydroxycholecalciferol D), which is further converted in the kidney to calcitriol (1,25-dihydroxycholecalciferol D). One of calcitriol's most important functions is to promote calcium uptake by the intestines. Cholecalciferol is present in food such as fatty fish, beef liver, eggs, and cheese. In some countries, cholecalciferol is also added to products like plants, Group of fat-soluble secosteroids For other uses, see Vitamin D (disambiguation). This article is about the family of D-"vitamins". For individual forms, see ergocalciferol, cholecalciferol, vitamin D4, vitamin D5, and calcitriol. Vitamin D is a group of structurally related, fat-soluble compounds responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, along with numerous other biological functions. In humans, the most important compounds within this group are vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol). Unlike the other twelve vitamins, vitamin D is only conditionally essential - in a preindustrial society people had adequate exposure to sunlight and the vitamin was a hormone, as the primary natural source of vitamin D was the synthesis of cholecalciferol in the lower layers of the skin's epidermis, triggered by a photochemical reaction with ultraviolet B (UVB) radiation from sunlight. Cholecalciferol and ergocalciferol can also be obtained through diet and dietary supplements. Foods such as the flesh of fatty fish are good natural sources of vitamin D; there are few other foods where it naturally appears in significant amounts. In the U.S. and other countries, cow's milk and plant-based milk substitutes are fortified with vitamin D3, as are many breakfast cereals. Government dietary recommendations typically assume that all of a person's vitamin D is taken by mouth, given the potential for insufficient sunlight exposure due to urban living, cultural choices for the amount of clothing worn when outdoors, and use of sunscreen because of concerns about safe levels of sunlight exposure, including the risk of skin cancer. However, for most people, skin synthesis contributes more than diet sources. Cholecalciferol is converted in the liver to calcifediol (also know
Vitamin D