Nappo berna biography of martin

Music to follow you through the night.

00:00 Kirk Whalum - Can We Talk
00:04 Dave Koz & Boney James - When Will I Know For Sure
00:09 Acoustic Alchemy - Silent Partner
00:13 Sheila E and the E Train - Passing Through
00:19 Carmen Cuesta Loeb - Shape Of My Heart
00:25 David P Stevens - Sensitivity (Philly Remix)
00:30 Jeffery Smith - The Chill Zone
00:36 Roberto Vazquez -Simple Life
00:41 Jackiem Joyner - Later Tonight
00:45 Bob James - Glass Hearts
00:50 Walle Larsson - One Step Closer
00:54 Jonathan Fritzen - Midnight Secrets
00:59 Martin Fietz - Sea View
01:04 Mesa Project (Sarai Usry and Michael E) - Stay The Night
01:10 Hiroko Kokubu - Night in Capri
01:15 Gary Little - DayDream
01:18 Brian Simpson - I Remember When
01:22 Rocco Ventrella - I Receive Your Love
01:27 Gordon James - Sunshine
01:32 Phil Denny - Sway Back
01:35 Nappo Berna - Midnight Angel

Le Infezioni in Medicina

• Vol. 32, No. 4, 2024

"Le Infezioni in Medicina" is a peer-reviewed quarterly journal which publishes, free of charge, editorials, reviews, original articles, case reports and letters to the Editor on experimental and clinical investigations concerning any aspect of infectious diseases. A special section is concerned with historical aspects of infectious diseases.
"Le Infezioni in Medicina", first issued in March 1993, is published in Italy and the official language is English. The logo reported on the cover sheet is the ancient alchemic symbol representing in 15th century the process of purification.
The Editorial Board includes many outstanding infectious disease specialists and clinical microbiologists from most part of the word. All manuscripts submitted for publication, are peer reviewed for their clinical relevance, technical accuracy, clarity and objectivity and, if accepted, are shortly published. Contributions from all over the world are welcome under the only criterion of scientific quality.
By September 2017, "Le Infezioni in Medicina" is the "Official Journal of the Italian Society of Infectious and Tropical Diseases". The aim of the journal is to publish original and high-quality papers on all aspects of infections: clinical, microbiological, diagnostic and epidemiological, bringing together the knowledge and expertise from all specialties involved in infection research and clinical practice, and taking into consideration the continuous changes in the field of infections. Each issue of the journal is well balanced in the typology of articles presented, bringing readers some high-quality reviews dealing with specific hot topics of interest and several original articles referring to unpublished studies on both experimental and clinica

Abstract

The incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP NEN) is increasing at a rapid pace and is becoming an increasingly important consideration in clinical care. Epidemiological data from multiple countries indicate that the incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP NEN) exhibits regional, site-specific, and gender-based variations. While the genetics and pathogenesis of some GEP NEN, particularly pancreatic NENs, have been investigated, there are still many mechanisms that require further investigation. The management of GEP NEN is diverse, but surgery remains the primary option for most cases. Peptide receptor radionuclide therapy (PRRT) is an effective treatment, and several clinical trials are exploring the potential of immunotherapy and targeted therapy, as well as combination therapy.

Keywords: gastroenteropancreatic neuroendocrine neoplasm, epidemiology, treatment, neuroendocrine tumor, genetics

1. Introduction

Neuroendocrine neoplasm (NEN) is a heterogeneous group of tumors originating from the diffuse neuroendocrine system (1). NEN can be present in any part of the body and can lead to various hormonal syndromes (2). The gastroenteropancreatic (GEP) NEN represents the most prevalent site of NEN, accounting for approximately 55% to 70% of the total number of NEN cases (3, 4). GEP NEN is primarily observed in the foregut, midgut, and hindgut (5). NEN can manifest in other locations, including the lungs, thymus, parathyroid, thyroid, adrenal glands, and pituitary glands (6). Furthermore, approximately 10% of NEN cases are associated with genetic syndromes, including multiple endocrine neoplasia type 1, von Hippel-Lindau and neurofibromatosis type 1 (7).

The occurrence of GEP NEN is rare (1). However, the global incidence of NENs has increased markedly over the past few decades, particularly in North America, and the clinical significance of NENs is becoming increasingly important (8, 9). The data from